and process for prodcuing protein wtih use of the microbe as host
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United States of America Patent
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Feb 2, 2010
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N/A
app pub date -
Nov 8, 2004
filing date -
Nov 11, 2003
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Abstract
is used as a host for the production of protein pharmaceuticals and the like, it is also desired that it does not form spores and is readily sterilized. The above problems have been solved by inactivating the sporulation-associated gene thereof and by cloning and inactivating the extracellular and intracellular protease genes thereof.
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