Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
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United States of America Patent
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Jan 19, 2010
Grant Date -
Sep 27, 2007
app pub date -
Feb 14, 2007
filing date -
Sep 9, 2002
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Abstract
Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
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