Biodegradable oxidized cellulose esters and their uses as microspheres
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United States of America Patent
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Jan 19, 2010
Grant Date -
Jun 16, 2005
app pub date -
Oct 28, 2004
filing date -
Dec 6, 2001
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Abstract
A new cellulose excipient, OCCAE, suitable for use as a binder, filler, and/or disintegrant in the development of solid dosage forms and as a bodying agent or a drug carrier in the preparation of topical formulations is described. The cellulose excipient is formed by reacting an oxidized cellulose ester with an alcohol in the presence of a catalyst. The invention also describes the formation of controlled release microspheres using OCCAE and/or oxidized cellulose esters that may be used to control the release of drug in a patient over a time period of several hours to several days.
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