Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
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United States of America Patent
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Jan 12, 2010
Grant Date -
Dec 6, 2007
app pub date -
Apr 10, 2007
filing date -
Oct 15, 2004
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Abstract
Non-peptide compounds having activity as selective antagonists of bradykinin (BK) B2 receptor are disclosed. The compounds have the general formula (I)can be independently a group which is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, or n-pentyl; and the enantiomers and enantiomeric mixtures thereof. Pharmaceutical compositions containing these compounds and methods of using the compounds to treat patients having conditions, disorders or diseases involving activation of bradykinin B2 receptors are also disclosed.
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