Zinc-containing sustained-release composition, its preparation, and method for producing the same
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United States of America Patent
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Jan 5, 2010
Grant Date -
Sep 21, 2006
app pub date -
Apr 1, 2004
filing date -
May 1, 2003
priority date (Note) -
Expired
status (Latency Note)
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Abstract
With a simple and high-yield production method, a zinc-containing sustained-release composition capable of stabilizing a physiologically active protein or peptide, typically G-CSF by precipitation and retaining drug efficacy for several days in a living body owing to its sustained releasability is provided. Concretely, a zinc-containing sustained-release composition produced by forming a precipitate by mixing a physiologically active protein or peptide, a water-soluble zinc salt, a water-soluble carbonate and/or a water soluble phosphate aqueous solution. The zinc-containing sustained-release composition may be administered as a zinc-containing sustained preparation by adding a pharmaceutically acceptable additive as is necessary.
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