Methods of upmodulating an immune response with non-activating forms of B7-4
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United States of America Patent
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Dec 29, 2009
Grant Date -
Aug 30, 2007
app pub date -
Aug 31, 2006
filing date -
Aug 23, 1999
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Abstract
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in a immune cell resulting in modulation of the immune response.
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