Imaging microarrays
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United States of America Patent
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Dec 22, 2009
Grant Date -
Jul 3, 2003
app pub date -
Oct 11, 2002
filing date -
Oct 12, 2001
priority date (Note) -
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Abstract
A method of obtaining a corrected image of a microarray includes acquiring an image of a microarray including a target spot, and processing the image to correct for background noise and chip misalignment. The method also includes analyzing the image to identify a target patch, edit debris, and correct for ratio bias; and detecting single copy number variation in the target spot using an objective statistical analysis that includes a t-value statistical analysis. The method provides statistically robust computational processes for accurately detecting genomic variation at the single copy level.
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