Process for the preparation of 3-amino-pentan-1,5-diol
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United States of America Patent
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Dec 22, 2009
Grant Date -
Dec 18, 2008
app pub date -
Jun 9, 2008
filing date -
Jun 15, 2007
priority date (Note) -
Expired
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Abstract
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-kinase inhibitor useful in the treatment of rheumatoid arthritis.
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