Process for the preparation of oligonucleotides
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United States of America Patent
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Dec 22, 2009
Grant Date -
Jul 6, 2006
app pub date -
Dec 16, 2003
filing date -
Dec 18, 2002
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Abstract
A process for the synthesis of an oligonucleotide is provided in which an oligonucleotide is assembled on a swellable solid support using the phosphoramidite approach in the presence of an activator, wherein the activator is not tetrazole or a substituted tetrazole. Preferred activators are pyridinium, imidazolinium and benzimidazolinium salts; benzotriazole and derivatives thereof; and saccharin or a saccharin derivative. Preferred swellable solid supports comprise functionalised polystyrene, partially hydrolysed polyvinylacetate or poly(acrylamide).
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