Modified annexin proteins and methods for their use in organ transplantation
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United States of America Patent
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Dec 22, 2009
Grant Date -
May 18, 2006
app pub date -
Nov 3, 2005
filing date -
Feb 21, 2001
priority date (Note) -
Expired
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Abstract
Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrhage and to attenuate ischemia-reperfusion injury (IPI), are also provided. The modified annexins bind phosphatidylserine (PS) on cell surfaces, thereby preventing the assembly of the prothromkinase complex. The modified annexin decreases the binding of leukocytes and platelets during post-ischemic reperfusion, thereby restoring microvascular blood flow and decreasing organ damage.
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