Methods of identifying respondents to hypoxia inducible factor 1-α inhibitors
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United States of America Patent
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Dec 8, 2009
Grant Date -
Dec 7, 2006
app pub date -
Apr 17, 2006
filing date -
Aug 30, 2004
priority date (Note) -
Expired
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Abstract
This invention relates to methods of measuring HIF expression and activity, as well as measuring inhibition of HIF following administration of an HIF inhibitor useful in treating HIF related diseases. The present invention further relates to methods of identifying individuals who will respond to HIF inhibitors. The invention also relates to methods of monitoring a patient response to a given dosage of an HIF inhibitor. The invention also includes assays and kits for performing the methods described herein.
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