Treatment of patients with dysfunctional cardiac sodium channels
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United States of America Patent
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Dec 1, 2009
Grant Date -
Sep 4, 2008
app pub date -
Oct 29, 2007
filing date -
Oct 27, 2006
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Abstract
Isolated peptides and polynucleotides are provided that can be used to treat a subject that has a genetic predisposition to, or has been diagnosed as having, a cardiac disorder related to dysfunctional sodium channels. Also provided are methods of treatment, as well as methods of predicting the occurrence of a cardiac event or the severity or prognosis of cardiac symptoms, in a subject that has either been diagnosed as having, or is suspected of developing, a sodium channel related cardiac disorder, by testing the subject for the presence of H558R-polymorphism on the subject's SCN5A gene.
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