Determining the risk of human anti-human antibodies in transgenic mice
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United States of America Patent
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Dec 1, 2009
Grant Date -
Jan 26, 2006
app pub date -
May 23, 2005
filing date -
Mar 19, 2004
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Abstract
The present embodiments relate to methods of identifying and creating human or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for screening for anti-HAHA compounds are also included. Methods for determining if various conditions for administering an antibody to a subject enhance or suppress a HAHA response are also included.
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