Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis
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United States of America Patent
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Nov 24, 2009
Grant Date -
Apr 26, 2007
app pub date -
Dec 17, 2004
filing date -
Dec 18, 2003
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Abstract
The present invention is directed to novel derivatives of gambogic acid and analogs thereof. The present invention also relates to the discovery that novel derivatives of gambogic acid are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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