Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
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United States of America Patent
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Nov 24, 2009
Grant Date -
Jun 5, 2008
app pub date -
Oct 1, 2007
filing date -
Oct 3, 2006
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Abstract
This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds. This invention further is directed to the pharmaceutical use of the compounds for inhibiting GSK3β kinase and/or modulating N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders.
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