Low-density lipoprotein receptor 6 (LRP6) as a mammary stem cell marker and related methods
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United States of America Patent
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Nov 24, 2009
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Dec 20, 2007
app pub date -
May 30, 2007
filing date -
May 30, 2006
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Abstract
A method for enriching a population of somatic mammary stem cells or mammary tumor stem cells based on low-density lipoprotein receptor-related protein 6 (LRP6). Also included are methods for screening for LRP6 modulators, as well as methods for reducing Wnt signaling, for treating Wnt signaling-related diseases, for detecting mammary basal-like cells, for diagnosing basal-like breast cancer, and for inhibiting proliferation of a tumor expressing LRP6, and compositions thereof.
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