Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby
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United States of America Patent
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Nov 10, 2009
Grant Date -
May 27, 2004
app pub date -
Sep 15, 2003
filing date -
Sep 13, 2002
priority date (Note) -
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Abstract
bacteria, which can then be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be used to generate antibodies useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.
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