Industrial process for the synthesis of 2-substituted 1-(hydroxy-ethylidene)-1,1-bisphosfi- conic acids of high purity and the salts thereof

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United States of America Patent

PATENT NO 7612229
SERIAL NO

10541866

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Abstract

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Process for the synthesis of high purity 2-substituted-1-(hydroxy-ethylidene)-1,1-bisphosphonic acid of formula (I), the salts and hydrates thereof—wherein the meaning of R is 3′-pyridyl or 2′-amino-ethylidene group—from compounds of formula (II)—wherein the meaning of R is as described above—or salts and hydrates thereof with phosphorous acid in the presence of methanesulfonic acid using phosphorus pentoxide as reagent and in given case the obtained acid is converted into a salt with base.

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Patent Owner(s)

Patent OwnerAddress
RICHTER GEDEON VEGYESZETI GYAR RT19-21 GYOMROI UT 1103 BUDAPEST

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Demeter, Adam Budapest , HU 4 8
Fischer, Janos Budapest , HU 14 24
Fodor, Tamas Budapest , HU 8 8
Gizur, Tibor Budapest , HU 9 16
Levai, Sandor Biatorbagy , HU 4 5
Neu, Jozsef Budapest , HU 9 38
Perenyi, Eva Budapest , HU 1 2
Törley, Jozsef Budapest , HU 3 1

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