Method of generating islet beta-cells from exocrine pancreatic cells
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United States of America Patent
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Oct 20, 2009
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app pub date -
Jun 21, 2004
filing date -
Jun 20, 2003
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Abstract
The present invention discloses an in vitro method wherein mammalian beta-cell differentiation can be induced in dedifferentiated exocrine pancreatic cells in a medium comprising ligands of the EGF receptor and the GP130 receptor, such as EGF and LIF. Insulin secreting cells, obtainable by this method, provide a means for the treatment of diabetes by islet transplantation.
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