Estimation method, human estrogen receptor alpha gene, genomic DNA, and diagnostic marker

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United States of America Patent

PATENT NO 7601828
APP PUB NO 20070269809A1
SERIAL NO

11434940

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Abstract

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Evaluation methods for evaluating susceptibility to multifactorial diseases in sexual differentiation disorders, human estrogen receptor alpha (α) genes carrying single nucleotide polymorphisms (SNPs) associated with the multifactorial diseases, DNAs containing the nucleotides at the SNPs, and diagnostic markers containing the DNAs are provided. Susceptibility to the multifactorial diseases can be evaluated by examining at least one of SNPs 8 to 14, or SNPs 10 to 14, in a human estrogen receptor α gene, and more precisely evaluated by examining a diplotype encompassing SNPs 10 to 14.

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Patent Owner(s)

Patent OwnerAddress
KEIO UNIVERSITY15-45 MITA 2-CHOME MINATO-KU TOKYO 1088345
STAGEN CO LTDTAITO-KU TOKYO 111-0051
JAPAN HEATH SCIENCES FOUNDATION13-4 NIHONBASHI KODENMA-CHO CHUO-KU TOKYO 103-0001

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hasegawa, Tomonobu Tokyo , JP 5 33
Kamatani, Naoyuki Tokyo , JP 13 57
Ogata, Tsutomu Tokyo , JP 10 92

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