Methods and compositions for heat activated gene therapy using cytolethal distending toxin
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United States of America Patent
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Sep 29, 2009
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app pub date -
Jan 23, 2004
filing date -
Jan 24, 2003
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Abstract
The invention provides compositions and methods for gene therapy using cytolethal distending toxins (CDTs). In a preferred embodiment, a gene therapy vector according to the invention includes a gene encoding a B subunit of a CDT and an antisense oligonucleotide that inhibits a DNA repair mechanism. An inducible promoter is operably linked to the gene and oligonucleotide. Preferably, the promoter is strictly inducible by heat shock.
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