Stabilized viral envelope proteins and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7592014
APP PUB NO 20060094049A1
SERIAL NO

11261390

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Abstract

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This invention provides an isolated nucleic acid which comprises a nucleotide segment having a sequence encoding a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral envelope protein contains one or more mutations in amino acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. This invention also provides a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral envelope protein contains one or more mutations in amino acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. This invention further provides methods of treating HIV-1 infection.

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Patent Owner(s)

Patent OwnerAddress
PROGENICS PHARMACEUTICALS INCNORTH BILLERICA MASSACHUSETTS 01862

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Binley, James M Brooklyn , US 5 79
Maddon, Paul J Scarsdale , US 89 993
Moore, John P New York , US 20 295
Olson, William C Ossining , US 69 956
Schuelke, Norbert New City , US 9 168

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