4-phenyl-pyrimidine-2-carbonitrile derivatives
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United States of America Patent
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Sep 15, 2009
Grant Date -
Apr 17, 2008
app pub date -
Jun 9, 2005
filing date -
Jun 11, 2004
priority date (Note) -
Expired
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Abstract
The invention relates to 4-phenyl-pyrimidine-2-carbonitrile derivatives having the general formula Iwherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising the derivatives as well as to the use thereof in the treatment of osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.
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