Reagent sets and gene signatures for renal tubule injury
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United States of America Patent
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Sep 15, 2009
Grant Date -
Mar 16, 2006
app pub date -
Jul 18, 2005
filing date -
Jul 19, 2004
priority date (Note) -
Expired
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Abstract
The invention discloses reagent sets and gene signatures for predicting onset of renal tubule injury in a subject. The invention also provides a necessary set of 186 genes useful for generating signatures of varying size and performance capable of predicting onset of renal tubule injury. The invention also provides methods, apparatuses and reagents useful for predicting future renal tubule injury based on expression levels of genes in the signatures. In one particular embodiment the invention provides a method for predict whether a compound will induce renal tubule injury using gene expression data from sub-acute treatments.
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