Method of estimating drug metabolic activity by analyzing mutations in glucuronosyl transferase gene
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United States of America Patent
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Sep 1, 2009
Grant Date -
Nov 16, 2006
app pub date -
Feb 13, 2003
filing date -
Aug 12, 2002
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Abstract
An object of this invention is to provide a method for assaying, predicting or assessing drug metabolism by effectively detecting (a) mutation(s) in a gene coding for UGT. A gene coding for UGT comprises 5 exons, and since the regions of exons 2 through 5 are common to each isoform of UGT1, by assaying a mutation in the common regions, particularly a mutation in exon 5 region, and further adding the detection of (a) mutation(s) in a plurality of exon regions, mutations of UGT1 gene can effectively assayed. A nucleic acid chip using nucleic acid probes is used as a way of detecting (a) mutation(s).
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