Cyclic peptides as G-protein-coupled receptor antagonists
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United States of America Patent
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Aug 25, 2009
Grant Date -
Sep 28, 2006
app pub date -
Oct 17, 2002
filing date -
Oct 17, 2001
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Abstract
The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions.
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