Method of assessing the effectiveness of a non-nucleoside reverse transcriptase inhibitor (NNRTI) on a human immunodeficiency virus type 1 (HIV-1)-infected patient
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United States of America Patent
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Aug 25, 2009
Grant Date -
Mar 17, 2005
app pub date -
Jan 14, 2004
filing date -
May 26, 1998
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Abstract
This invention relates to methods for assessing the effectiveness of non-nucleoside reverse transcriptase inhibitor on an HIV that rely on detection of combinations of mutations in HIV reverse transcriptase associated with altered susceptibility to such compounds. In some embodiments, the combinations of mutations include various combinations of mutations at codons 190, 101, 130, and 98 of HIV reverse transcriptase.
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