Antibody against von Willebrand factor cleaving enzyme and assay system using the same

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United States of America Patent

PATENT NO 7575872
APP PUB NO 20060251655A1
SERIAL NO

10529009

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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It is intended to provide an antibody showing immunoreactivity selectively to ADAMTS-13 and applications of this antibody in epitope analysis or diagnosis of an ADAMTS-13 autoantibody-positive patient. Alternatively, it is intended to provide a process for producing and use of a modified ADAMTS-13 molecule partially deleted aiming at the application in pharmaceutical products. An antibody specific for ADAMTS-13 which can be obtained from a warm-blooded animal immunized and sensitized with a polypeptide containing a part or the whole of ADAMTS-13 amino acid sequence; a process for producing an antibody comprising a step of immunizing and sensitizing a warm-blooded animal with a polypeptide containing a part or the whole of ADAMTS-13 amino acid sequence; use of the above-described antibody including a method of detecting and purifying ADAMTS-13; and a modified ADAMTS-13 molecule partially deleted are provided.

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Patent Owner(s)

Patent OwnerAddress
KM BIOLOGICS CO LTD1-6-1 OKUBO KITA-KU KUMAMOTO-SHI KUMAMOTO 860-8568

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hamamoto, Takayoshi Kumamoto, JP 10 152
Maeda, Hiroaki Kumamoto, JP 98 1001
Mimura, Noriko Kumamoto, JP 5 59
Nakagaki, Tomohiro Kumamoto, JP 14 82
Nozaki, Chikateru Kumamoto, JP 49 661
Soejima, Kenji Kumamoto, JP 32 192

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