Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs
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United States of America Patent
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Aug 11, 2009
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Aug 6, 2009
app pub date -
Sep 8, 2006
filing date -
Sep 9, 2005
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Abstract
Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selection of reagents in the fermentation feedstock, and selection of fermentation conditions.
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