Construct comprising recognition domain of antibody against von Willebrand factor-specific cleaving enzyme
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United States of America Patent
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Aug 11, 2009
Grant Date -
Oct 26, 2006
app pub date -
Mar 17, 2004
filing date -
Mar 17, 2003
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Abstract
The present invention provides an epitope recognized by an antibody (hereinafter, also referred to as an anti-ADAMTS-13 antibody) against a cleaving protease (hereinafter, also referred to as ADAMTS-13) specific to von Willebrand factor (hereinafter, also referred to as vWF), and a polypeptide comprising the epitope region. The present invention also provides a polypeptide located in a region from position 449 to position 687 in an amino acid sequence composing the ADAMTS-13, which is recognized by the anti-ADAMTS-13 antibody, or a peptide fragment derived from the polypeptide.
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