Crystal form of 5-hydroxy-1-methylimidazolidin-2,4-dione

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United States of America Patent

PATENT NO 7569701
APP PUB NO 20050143437A1
SERIAL NO

10508496

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Abstract

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Conventional I-form crystals of 5-hydroxy-1-methylhydantoin contain, remaining therein in a considerable amount, the organic solvent used in a purification step. In contrast, in II-form crystals, the amount of the organic solvent remaining therein is smaller than the detection limit. Namely, the II-form crystals contain substantially no residual organic solvent. The novel II-form crystals of 5-hydroxy-1-methylhydantoin obtained through recrystallization from water not only contain substantially no residual organic solvent, but also have a high bulk density and are hence advantageous for pharmaceutical preparation. They further have properties advantageous for production, such as low adhesion. The crystals are significantly useful as a material for medicines required to have high safety, such as drugs for renal insufficiency.

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Patent Owner(s)

Patent OwnerAddress
NIPPON ZOKI PHARMACEUTICAL CO LTD1-2 HIRANOMACHI 2-CHOME CHUO-KU OSAKA-SHI OSAKA 5410046

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ishii, Akira Hyogo , JP 192 1747
Nishimura, Naoharu Hyogo , JP 2 5
Okamoto, Kaoru Hyogo , JP 47 221

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