Detection of truncation mutations by mass spectrometry
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United States of America Patent
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Jul 21, 2009
Grant Date -
Mar 29, 2007
app pub date -
Jul 14, 2006
filing date -
Jul 30, 2004
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Abstract
This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as a mass difference.
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