Methods of quantifying methotrexate metabolites

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Jul 21, 2009
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Aug 30, 2002
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Aug 30, 2002

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Abstract

The present invention provides a method for efficiently converting methotrexate polyglutamates to methotrexate in a cellular extract by contacting the cellular extract with gamma glutamyl hydrolase under conditions suitable for efficient conversion of methotrexate polyglutamates to methotrexate.

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PROMETHEUS LABORATORIES INC	9410 CARROLL PARK DRIVE SAN DIEGO CA 92121

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C12Q:MEASURING OR TESTING PROCESSES INVOLVING ENZYMES O....

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Inventor Name	Address	# of filed Patents	Total Citations
Dervieux, Thierry	San Diego , US	34	131
Richerson, Russell B	Tucson , US	5	337

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Methods of quantifying methotrexate metabolites

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United States of America Patent

10232760

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US Family Size	Non-US Coverage
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DATE PUBLISHED	PUBLICATION/PATENT NO.	PUBLICATION TYPE
July 21, 2009	US,7563590,B2 US7563590B2	GRANTED PATENT AS SECOND PUBLICATION
March 04, 2004	US,20040043441,A1 US20040043441A1	FIRST PUBLISHED PATENT APPLICATION

PATENT NO	7563590
SERIAL NO	10232760
DOCKET NO

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10232760

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