Methods and compositions for impairing multiplication of HIV-1
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United States of America Patent
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Jul 21, 2009
Grant Date -
Sep 21, 2006
app pub date -
Feb 13, 2006
filing date -
Feb 15, 2005
priority date (Note) -
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Abstract
A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-1 Tat protein displayed in multiple strains and subtypes of HIV-1. This “pan-epitope” antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-1 infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-1 based on a measurement of the amount of Tat protein in a biological sample.
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