Therapeutic use of methionine to reduce the toxicity of platinum-containing anti-tumor compounds
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United States of America Patent
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Jul 7, 2009
Grant Date -
Jun 10, 2004
app pub date -
Oct 27, 2003
filing date -
Oct 3, 1996
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Abstract
Methods of preventing or reducing ototoxicity in patients undergoing treatment with therapeutically effective amounts of platinum-containing chemotherapeutic agents such as cisplatin or aminoglycoside antibiotics are provided. The methods comprise administering an effective amount of an otoprotective agent comprising methionine or a methionine-like moiety to said patient prior to, simultaneously with, or subsequently to administration of the platinum-containing chemotherapeutic agent or aminoglycoside antibiotic. Combinations of these time periods can also be employed.
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