Methods and compositions for treating intervertebral disc degeneration
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United States of America Patent
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Jul 7, 2009
Grant Date -
Jan 6, 2005
app pub date -
Mar 29, 2004
filing date -
Apr 7, 2000
priority date (Note) -
Expired
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Abstract
A fluid matrix comprising cross-linked remodelable collagen from a donor vertebrate animal is useful for regenerating hydrodynamic function in damaged intervertebral discs in vivo. The matrix may be injectable and may comprise cells and a plurality of purified cell growth factors. The matrix promotes cell growth and elaboration of proteoglycans to facilitate regeneration of native tissues. The collagen in the matrix may be cross-linked using photooxidative catalysis and visible light, and purified cell growth factors are preferably at least partly bone-derived.
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