G-CSF conjugates
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United States of America Patent
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Jun 23, 2009
Grant Date -
Jan 11, 2007
app pub date -
Aug 10, 2006
filing date -
Jan 10, 2000
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Abstract
Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a low in vitro bioactivity, a long in vivo half-life, a reduced receptor-mediated clearance, and provide a more rapid stimulation of production of white blood cells and neutrophils than non-conjugated recombinant human G-CSF.
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