Sulfur-containing naphthalimide derivatives
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United States of America Patent
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Jun 2, 2009
Grant Date -
May 25, 2006
app pub date -
Oct 31, 2005
filing date -
Apr 30, 2003
priority date (Note) -
Expired
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Abstract
The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.
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