Growth and differentiation of adult muscle stem cells with activators or inhibitors of Wnt signaling
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United States of America Patent
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Jun 2, 2009
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N/A
app pub date -
Dec 22, 2005
filing date -
Jun 25, 2003
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Abstract
Compositions and methods for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening methods to identify modulators are also provided. The methods of the invention may be conducted in vitro or in vivo to induce or inhibit stem cell proliferation and/or lineage commitment, and are particularly useful for in vivo stimulation of proliferation and/or lineage commitment of resident stem cells in a tissue.
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