Amine polymer-modified nanoparticulate carriers

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United States of America Patent

PATENT NO 7541017
APP PUB NO 20050192381A1
SERIAL NO

11036814

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Abstract

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The invention relates to a composition comprising a colloid which is stable under physiological pH and ionic strength, said colloid comprising particles having a silica core and a shell: a) wherein said shell comprises a cross-linked poly(ethylene)imine polymer having amine functionalities; b) wherein the particles have a volume-weighted mean particle size diameter of less than 200 nm, and c) wherein greater than 50% of said polymer in the colloid is bound to the core surfaces, wherein the polymer having amine functionalities has an average molecular weight less than 100,000 g/mol, the composition has a H of between 6 and 8; and d) wherein the colloid contains between 300 and 6000 .μmol amine-monomer/g core particles.

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Patent Owner(s)

Patent OwnerAddress
BRUKER BIOSPIN CORPORATION15 FORTUNE DRIVE BILLERICA MA 01821

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bringley, Joseph F Rochester, US 91 555
Harder, John W Rochester, US 45 296
Hewitt, James M Fairport, US 4 41
Qiao, Tiecheng A Webster, US 44 459
Wunder, Andrew Lyons, US 1 12

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