Methods of facilitating vascular growth in cardiac muscle and methods for the production of recombinant EMAP II
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United States of America Patent
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May 26, 2009
Grant Date -
Nov 15, 2001
app pub date -
Dec 8, 2000
filing date -
Dec 23, 1999
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Expired
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Abstract
A method of facilitating vascular growth in cardiac muscle of a subject in need of such treatment comprises inhibiting EMAP II activity in said subject by an amount effective to stimulate vascular growth in said cardiac muscle. The inhibiting step may be carried out by any suitable means, such as: By administering a compound (e.g., an antibody) that specifically binds to EMAP II to said subject in an amount effective to stimulate vascular growth in said cardiac muscle; by downregulating EMAP II expression in said subject by an amount effective to stimulate vascular growth in said cardiac muscle (e.g., by administration of an antisense olgionucleotide); or by administering an EMAP II receptor antagonist to said subject in an amount effective to stimulate vascular growth in said cardiac muscle.
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