Animal model and cell-line expressing modified chlorine channel
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United States of America Patent
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May 19, 2009
Grant Date -
Dec 30, 2004
app pub date -
Jul 18, 2003
filing date -
Jan 23, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to a test system for the identification and testing of active compounds which act on synapic transmission (active compounds for treatment of neuronal diseases), which influence endo/exocytosis, which influence processing of proteins and in particular of active compounds which can be used for treatment of osteoporosis or Paget's disease, for treatment of neurological and neuromuscular diseases and other nerve diseases or as psychotropic pharmaceuticals. The invention furthermore relates to a genetically modified non-human mammal, in which one or more chloride channels from the group consisting of C1C-3, C1C-4, C1C-6 and C1C-7 are not expressed or are expressed non-functionally, and somatic cell lines which are derived from such an animal, and the use thereof for the identification and testing of substances which are suitable for inhibiting chloride channels, in particular C1C-3, C1C-4, C1C-5, C1C-6 and/or C1C-7.
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