Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices
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United States of America Patent
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May 12, 2009
Grant Date -
Jul 19, 2007
app pub date -
Jan 5, 2007
filing date -
Jan 11, 2006
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Abstract
The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.
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