Nucleic acid hybridization methods

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United States of America Patent

PATENT NO 7531306
APP PUB NO 20050176035A1
SERIAL NO

10996621

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Abstract

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Disclosed herein are methods of destabilizing double-stranded nucleic acid hybridization using an enzyme comprising DNA N-glycosylase activity. Also disclosed herein is the detection of a double-stranded target DNA wherein the hybridization of duplex strands has been at least partially disrupted thereby permitting invasion of a probe strand. Also disclosed herein are methods of using an enzyme comprising DNA N-glycosylase activity to generate single-stranded circular nucleic acids.

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Patent Owner(s)

Patent OwnerAddress
GENEOHM SCIENCE INC6146 NANCY RIDGE LANE SUITE 101 SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crothers, Donald M Northford , US 21 895

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