Cyclic malonamides as inhibitors of aβ protein production

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United States of America Patent

PATENT NO 7528249
APP PUB NO 20080275024A1
SERIAL NO

12142145

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention relates to novel cyclic malonamides having the formula (I):to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

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Patent Owner(s)

  • BRISTOL-MYERS SQUIBB PHARMA COMPANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Olson, Richard E Wilmington, US 142 1446
Yang, Michael G Wilmington, US 58 561

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