Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof
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United States of America Patent
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Apr 28, 2009
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May 10, 2002
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May 10, 2001
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Abstract
The present invention provides a crystal of human beta-secretase (BACE) having monoclinic space group symmetry C2, in a representative example, comprising a unit cell having dimensions of a, b, and c, wherein a is about 53 Å to about 103 Å, b is about 85 Å to about 125 Å, c is about 40 Å to about 60 Å, and α=γ=90°, and β is about 85° to about 105°, and in a preferred example, comprising unit cell dimensions as follows: a is 73.1 Å, b is 105.1 Å, c is 50.5 Å, and α=γ=90°, and β is 94.8, wherein the Matthews coefficient of said crystal is 2.1 Å/Da with 42% solvent, and wherein said crystal diffracts to 1.7 Å resolution.
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