Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells
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United States of America Patent
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Apr 21, 2009
Grant Date -
Feb 13, 2003
app pub date -
Nov 15, 2001
filing date -
May 12, 2000
priority date (Note) -
Expired
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Abstract
The present invention relates to polypeptide compositions which bind to cell surface epitopes and, in multivalent forms, cause or lead to the killing of cells including lymphoid tumor cells, and in the case of monovalent forms, cause immunosuppression or otherwise inhibit activation of lymphocytes. The invention further relates to nucleic acids encoding the polypeptides, methods for the production of the polypeptides, methods for killing cells, methods for immunosuppressing a patient, pharmaceutical, diagnostic and multivalent compositions and kits comprising the polypeptides and uses of the polypeptides.
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