Gene therapy for tumors using minus-strand RNA viral vectors encoding immunostimulatory cytokines
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United States of America Patent
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Apr 21, 2009
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Jan 12, 2005
filing date -
Jan 13, 2004
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Abstract
The present invention provides methods for treating tumors, which comprise the step of administering into tumor sites a minus-strand RNA viral vector encoding an immunostimulatory cytokine or cells introduced with the vector. The present invention also provides compositions for treating tumors, which comprise as an active ingredient the minus-strand RNA viral vector encoding an immunostimulatory cytokine or cells introduced with the vector. The present invention also provides kits for treating tumors, which comprise the minus-strand RNA viral vector encoding an immunostimulatory cytokine, and a tumor antigen or a vector expressing the antigen.
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