Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
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United States of America Patent
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Apr 14, 2009
Grant Date -
Aug 18, 2005
app pub date -
Oct 13, 2004
filing date -
Apr 9, 2003
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Abstract
The present invention provides compositions and methods for reversibly inhibiting S-adenosyl-L-homocysteine (SAH) hydrolase. The compounds of the present invention can be used as an anti-hemorrhagic viral infection agent, an immunosuppressant, a homocysteine lowering agent, or an anti-neoplasm agent. The compositions and methods of the present invention can be used for the prevention and treatment of hemorrhagic virus infection, autoimmune diseases, autograft rejection, neoplasm, hyperhomocysteineuria, cardiovascular disease, stroke, Alzheimer's disease, multiple sclerosis or diabetes. The compound of the present invention and/or used in the present invention has the formula (I):
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