Position-independent and tissue specific expression of a transgene in milk of transgenic animals
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United States of America Patent
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Mar 31, 2009
Grant Date -
Dec 30, 2004
app pub date -
Dec 21, 2001
filing date -
Dec 22, 2000
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Abstract
The present invention relates to an isolated insulator DNA molecule consisting of the 5′ and 3′ regions of the porcine wrap gene locus and a method for insulating the expression of an introduced heterologous gene from silencing and variegation effect in chromatin into which the gene has integrated. The invention is also directed to mammalian cells comprising said insulator DNA molecule and non human animals obtained therefrom, which are preferably able to express a polypeptide of interest in milk.
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